Pharmaceutical biotechnology : fundamentals and applications


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Crommelin is co-founder of OctoPlus, a Leiden based company specialized in the development of pharmaceutical product formulations and advanced drug delivery systems. Meibohm obtained his doctoral degree in Pharmaceutics from the Technical University Carolo-Wilhelmina, Braunschweig, Germany and received postdoctoral training at the University of Florida, Gainesville.

Meibohm is a fellow of the American Association of Pharmaceutical Scientists and the American College of Clinical Pharmacology, and has published three textbooks, more than 90 peer-reviewed research articles and book chapters, abstracts, and over invited scientific presentations to national and international audiences.

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Pharmaceutical biotechnology - concepts and applications

Pharmaceutical Biotechnology : Fundamentals and Applications. Daan J. Crommelin , Robert D.


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Each route has its own advantages and disadvantages, such as the rate of drug release and its clearance, which may have an impact on the dosage level. The book describes the various options that need to be considered when determining which delivery method should be adopted.

Pharmaceutical Biotechnology: Fundamentals and Applications

It is important to patent any biomolecule which might have pharmaceutical value. A patent prevents others from exploiting the innovation for up to 20 years. Naturally occurring products cannot be patented unless they involve substantial post-extraction development. The book explains the steps involved, with examples from currently available drugs on the market, including those details that need to be considered at each step.

The book next describes the process involved in taking a potentially marketable drug into clinical trials, where pharmacokinetic and pharmacodynamic experiments reveal the drug's fate and its mode of action in the body, and where the drug's potential toxicity and immunogenicity are assessed. Prior to the trial, approvals need to be obtained from the appropriate regulatory authorities eg the US Food and Drug Administration , and, of course, the manufacturing facility must comply with industry safety and quality standards.

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After the drug enters the market, post-marketing surveillance must be carried out to track any side effects or adverse reactions. The book also contains separate chapters dedicated to biochemical pathways that are commonly targeted by drugs that are on the market, with case studies and their medical uses: cytokines, interferons eg Rebif, interferon beta-1a , interleukins eg Ontak, denileukin difitox , tumour necrosis factors eg Beromun, tasonermin , growth factors eg Neupogen, filgrastim , hormones eg Humalog, insulin lispro , enzymes eg Benefix, nonacog alfa , antibodies eg Avastin, bevacizumab and vaccines eg Engerix B, hepatitis B virus coat.

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There is also a separate chapter dedicated to nucleic acid- and cell-based therapeutic strategies such as gene therapy and stem cells. For an investigator like me, who is involved in fundamental research, reading this book was an educational journey that familiarised me with several applicationend topics.

Pharmaceutical biotechnology - concepts and applications

The book's strong point is certainly the depth and breadth of the topics covered, and hence I recommend the book both to basic scientists and to more seasoned researchers in the field of pharmaceutical biotechnology. National Center for Biotechnology Information , U.

Journal List Hum Genomics v. Hum Genomics.

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This book is written by author Bernd Meibohm. You can read the Pharmaceutical Biotechnology : Fundamentals and Applications, Third Edition book on our website emmabowey. If visitor interest this book, visitor mustfor info, we are no place the pdf on my blog, all of file of.

Completely revised text that reflects to emergent trends and cutting-edge advances in pharmaceutical biotechnology, this Third Edition provides a well-balanced framework for understanding every major aspect of pharmaceutical biotechnology, including drug development, production, dosage forms, administration, and therapeutic developments.

Pharmaceutical Biotechnology Fundamentals and Applications

New chapters cover evolving areas regarding biopharmaceuticals, including oligonucleotides, siRNA and various monoclonal antibodies, immunogenicity, gene therapy, and the regulatory issues factoring into the biopharmaceutical approval process.

Pharmaceutical biotechnology : fundamentals and applications Pharmaceutical biotechnology : fundamentals and applications
Pharmaceutical biotechnology : fundamentals and applications Pharmaceutical biotechnology : fundamentals and applications
Pharmaceutical biotechnology : fundamentals and applications Pharmaceutical biotechnology : fundamentals and applications
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